
Basal cell carcinoma (BCC) is a common type of skin cancer that can be challenging to treat in advanced stages. Join Karl Lewis, MD, and Aleksandar Sekulic, MD, PhD, as they discuss the importance of the hedgehog pathway in the pathogenesis of BCC and the role of hedgehog inhibitors in advanced BCC. Evidence related to the safety and efficacy of the approved hedgehog inhibitors sonidegib and vismodegib is discussed, with recommendations for optimizing their use. Case studies are utilized to share the faculty’s experience in treating patients with hedgehog inhibitors, including strategies to manage resistance.
Course Credit:
2.00 AMA PRA Category 1 CreditsTM
Dates:
Opens: 2021-02-17
Closes: 2022-02-17
Target Audience:
This activity is intended for a national audience of oncologists, dermatologists, dermato-oncologists, and Mohs surgeons.
This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi Genzyme.
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Karl D. Lewis, MD
Associate Professor of Medicine
Division of Medical Oncology
University of Colorado
Medical Oncologist
UCH - Cancer Center
Aurora, Colorado -
Aleksandar Sekulic, MD, PhD
Deputy Director, Mayo Clinic Cancer Center
Associate Director, Center for Individualized Medicine
Vice Chair, Department of Dermatology
Chair, Cutaneous Oncology Disease Group
Mayo Clinic Scottsdale
Scottsdale, Arizona
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Learning Objectives
- Explain how the target pathways of systemic treatment for advanced basal cell carcinoma (BCC) align with the current understanding of the pathogenesis of the disease
- Evaluate the profiles of and clinical data related to current and emerging systemic treatments to support the optimal care of patients with advanced BCC
- Create systemic treatment plans for patients with advanced BCC who are intolerant to hedgehog pathway inhibitors
- Identify opportunities to improve the management of patients with advanced BCC whose disease has progressed despite previous treatment with hedgehog pathway inhibitors
Faculty Disclosures
Karl D. Lewis, MD
Advisory Board: Regeneron, Eisai
Aleksandar Sekulic, MD, PhD
No relationships to disclose.Accreditation and Certification
The Annenberg Center for Health Sciences at Eisenhower is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Additional Content Planners
Kam A. Newman, MD (Peer Reviewer)No significant relationships to disclose.
Gregory Scott, PharmD, RPh (Medical Writer)
No significant relationships to disclose.
Annenberg Center for Health Sciences
All members of the Eisenhower Health Education Committee have no relevant commercial relationships to disclose.